ULK3 antibody (C-Term)

Catalog No. ABIN6243328

This anti-ULK3 antibody is a Mouse Monoclonal antibody detecting ULK3 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for ULK3 antibody (C-Term) (ABIN6243328)

Target: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ULK3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1404CT148-89-25

Product Details anti-ULK3 Antibody

Binding Specificity: AA 435-468, C-Term

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This ULK3 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the C-terminal region of human ULK3.

Isotype: IgG1 kappa

Application Details

Application Notes: IHC: 1:50. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for ULK3

Target: ULK3 (Unc-51-Like Kinase 3 (ULK3))

Alternative Name: ULK3

Background: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.

Molecular Weight: 53444

UniProt: Q6PHR2