RNF126 antibody (AA 84-115)

Catalog No. ABIN6243426

Product Details anti-RNF126 Antibody

Target: RNF126 (Ring Finger Protein 126 (RNF126))

Binding Specificity: AA 84-115

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF126 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RNF126 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-115 amino acids from the Central region of human RNF126.

Clone: RB54136

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for RNF126

Target: RNF126 (Ring Finger Protein 126 (RNF126))

Alternative Name: RNF126 (RNF126 Products)

Synonyms: 2610010O19Rik antibody, ring finger protein 126 antibody, RNF126 antibody, Rnf126 antibody

Background: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:< a href="http://www.uniprot.org/citations/24981174" target="_blank">24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:< a href="http://www.uniprot.org/citations/24275455" target="_blank">24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:< a href="http://www.uniprot.org/citations/23026136" target="_blank">23026136). May monoubiquitinate AICDA (PubMed:< a href="http://www.uniprot.org/citations/23277564" target="_blank">23277564).

Molecular Weight: 33861

UniProt: Q9BV68