LARGE antibody (AA 365-398)

Catalog No. ABIN6243442

This anti-LARGE antibody is a Rabbit Polyclonal antibody detecting LARGE in WB. Suitable for Human.

Quick Overview for LARGE antibody (AA 365-398) (ABIN6243442)

Target: LARGE (Like-Glycosyltransferase (LARGE))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LARGE antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB55257

Product Details anti-LARGE Antibody

Binding Specificity: AA 365-398

Predicted Reactivity: C, Zf, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LARGE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 365-398 amino acids from the Central region of human LARGE.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for LARGE

Target: LARGE (Like-Glycosyltransferase (LARGE))

Alternative Name: LARGE

Background: Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine- beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:< a href="http://www.uniprot.org/citations/22223806" target="_blank">22223806). Phosphorylated O- mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:< a href="http://www.uniprot.org/citations/25279699" target="_blank">25279699).

Molecular Weight: 88066

UniProt: O95461