ALK antibody (C-Term)

Catalog No. ABIN6243476

This Rabbit Polyclonal antibody specifically detects ALK in IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for ALK antibody (C-Term) (ABIN6243476)

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALK antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1513-1514

Product Details anti-ALK Antibody

Binding Specificity: AA 1591-1620, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1591~1620 amino acids from the C-terminal region of human ALK.

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ALK antibody (ABIN6243476)

Liu, Mathialagan, Lappin, Fortner, Somps, Seitis, Johnson, Hu, Matsumoto: "Crizotinib reduces the rate of dark adaptation in the rat retina independent of ALK inhibition." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 143, Issue 1, pp. 116-25, (2016) (PubMed).

Target Details for ALK

Target: ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))

Alternative Name: ALK

Background: ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2,5)(p23,q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.

Molecular Weight: 176442

NCBI Accession: NP_004295

UniProt: Q9UM73

Pathways: RTK Signaling