ATG16L1 antibody

Catalog No. ABIN6243484

Cited in 1 publication. The Mouse Monoclonal anti-ATG16L1 antibody (Clone 54CT27-2-6) (ABIN6243484) specifically detects ATG16L1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for ATG16L1 antibody (ABIN6243484)

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ATG16L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 54CT27-2-6

Product Details anti-ATG16L1 Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: Purified His-tagged ATG16L1 protein(Fragment) was used to produced this monoclonal antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:60. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ATG16L1 antibody (ABIN6243484)

Martinez-Outschoorn, Trimmer, Lin, Whitaker-Menezes, Chiavarina, Zhou, Wang, Pavlides, Martinez-Cantarin, Capozza, Witkiewicz, Flomenberg, Howell, Pestell, Caro, Lisanti, Sotgia: "Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment." in: Cell cycle (Georgetown, Tex.), Vol. 9, Issue 17, pp. 3515-33, (2010) (PubMed).

Target Details for ATG16L1

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Alternative Name: ATG16L1

Background: The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 68265

NCBI Accession: NP_001177195, NP_001177196, NP_060444, NP_110430, NP_942593

UniProt: Q676U5

Pathways: Autophagy