Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

CHMP3 antibody (N-Term)

CHMP3 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB51722 unconjugated
Catalog No. ABIN6243582
  • Target See all CHMP3 Antibodies
    CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))
    Binding Specificity
    • 5
    • 1
    • 1
    • 1
    AA 28-61, N-Term
    Reactivity
    • 21
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 19
    • 2
    Rabbit
    Clonality
    • 20
    • 1
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CHMP3 antibody is un-conjugated
    Application
    • 14
    • 7
    • 5
    • 4
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B, Pr, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CHMP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 28-61 amino acids from the N-terminal region of human CHMP3.
    Clone
    RB51722
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))
    Alternative Name
    CHMP3 (CHMP3 Products)
    Synonyms
    CG9779 antibody, Dmel\\CG9779 antibody, Vps24 antibody, dvps24 antibody, vps24 antibody, VPS24 antibody, CHMP3 antibody, GB15107 antibody, wu:fb47g01 antibody, zgc:76972 antibody, NEDF antibody, 25.1 antibody, 4921505F14Rik antibody, 9130011K15Rik antibody, CGI-49 antibody, D6Ertd286e antibody, Vacuolar protein sorting 24 antibody, charged multivesicular body protein 3 antibody, SNF7 family protein antibody, hypothetical protein antibody, neuroendocrine differentiation factor, putative antibody, charged multivesicular body protein 3 S homeolog antibody, Vps24 antibody, chmp3 antibody, VPS24.2 antibody, CpipJ_CPIJ004098 antibody, PGTG_02107 antibody, LOC5569267 antibody, Smp_032150 antibody, CHMP3 antibody, LOC410607 antibody, Chmp3 antibody, chmp3.S antibody
    Background
    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
    Molecular Weight
    25073
    UniProt
    Q9Y3E7
You are here:
Support