KANK2 antibody (AA 343-376)

Catalog No. ABIN6243798

Product Details anti-KANK2 Antibody

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Binding Specificity: AA 343-376

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KANK2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KANK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 343-376 amino acids from the Central region of human KANK2.

Clone: RB48827

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for KANK2

Target: KANK2 (KN Motif and Ankyrin Repeat Domains 2 (KANK2))

Alternative Name: KANK2 (KANK2 Products)

Synonyms: ANKRD25 antibody, MXRA3 antibody, SIP antibody, AI504612 antibody, Ankrd25 antibody, BC010245 antibody, KN motif and ankyrin repeat domains 2 antibody, KANK2 antibody, Kank2 antibody

Background: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm, the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:< a href="http://www.uniprot.org/citations/24671081" target="_blank">24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis, proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:< a href="http://www.uniprot.org/citations/22371500" target="_blank">22371500). May be involved in promotion of cell proliferation (By similarity).

Molecular Weight: 91174

UniProt: Q63ZY3