EPH Receptor B3 antibody (AA 350-382)

Catalog No. ABIN6243857

This Rabbit Polyclonal antibody specifically detects EPH Receptor B3 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for EPH Receptor B3 antibody (AA 350-382) (ABIN6243857)

Target: EPH Receptor B3 (EPHB3)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPH Receptor B3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB50405

Product Details anti-EPH Receptor B3 Antibody

Binding Specificity: AA 350-382

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Ephb3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 350-382 amino acids from the Central region of Mouse Ephb3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for EPH Receptor B3

Target: EPH Receptor B3 (EPHB3)

Alternative Name: Ephb3

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. Beside its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

Molecular Weight: 109662

UniProt: P54754

Pathways: RTK Signaling