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R-Spondin 3 antibody (AA 214-248)

RSPO3 Reactivity: Human WB Host: Rabbit Polyclonal RB54573 unconjugated
Catalog No. ABIN6243983
  • Target See all R-Spondin 3 (RSPO3) Antibodies
    R-Spondin 3 (RSPO3)
    Binding Specificity
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 214-248
    Reactivity
    • 23
    • 9
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 18
    • 2
    • 2
    • 2
    • 1
    Rabbit
    Clonality
    • 21
    • 4
    Polyclonal
    Conjugate
    • 19
    • 2
    • 2
    • 2
    This R-Spondin 3 antibody is un-conjugated
    Application
    • 18
    • 13
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This RSPO3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 214-248 amino acids from human RSPO3.
    Clone
    RB54573
    Isotype
    Ig Fraction
    Top Product
    Discover our top product RSPO3 Primary Antibody
  • Application Notes
    WB: 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Target
    R-Spondin 3 (RSPO3)
    Alternative Name
    RSPO3 (RSPO3 Products)
    Synonyms
    pwtsr antibody, thsd2 antibody, cristin1 antibody, CRISTIN1 antibody, PWTSR antibody, THSD2 antibody, RGD1563246 antibody, 2810459H04Rik antibody, AW742308 antibody, Cristin1 antibody, Thsd2 antibody, R-spondin 3 antibody, rspo3 antibody, RSPO3 antibody, Rspo3 antibody
    Background
    Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.
    Molecular Weight
    30929
    UniProt
    Q9BXY4
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