R-Spondin 3 antibody (AA 214-248)

Catalog No. ABIN6243983

This Rabbit Polyclonal antibody specifically detects R-Spondin 3 in WB. It exhibits reactivity toward Human.

Quick Overview for R-Spondin 3 antibody (AA 214-248) (ABIN6243983)

Target: R-Spondin 3 (RSPO3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This R-Spondin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB54573

Product Details anti-R-Spondin 3 Antibody

Binding Specificity: AA 214-248

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RSPO3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 214-248 amino acids from human RSPO3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for R-Spondin 3

Target: R-Spondin 3 (RSPO3)

Alternative Name: RSPO3

Background: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Molecular Weight: 30929

UniProt: Q9BXY4