RIPK3 antibody

Catalog No. ABIN6243991

This anti-RIPK3 antibody is a Mouse Monoclonal antibody detecting RIPK3 in WB. Suitable for Human.

Quick Overview for RIPK3 antibody (ABIN6243991)

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RIPK3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 2013CT892-86-49

Product Details anti-RIPK3 Antibody

Predicted Reactivity: H

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This RIPK3 antibody is generated from a mouse immunized with a recombinate protein from the human region of human RIPK3.

Isotype: IgG1 kappa

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Alternative Name: RIPK3

Background: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Molecular Weight: 56887

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades