GP2 antibody (AA 35-179)

Catalog No. ABIN6252885

This Mouse Monoclonal antibody specifically detects GP2 in IHC (p), FACS and IF. It exhibits reactivity toward Human.

Quick Overview for GP2 antibody (AA 35-179) (ABIN6252885)

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GP2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: GP2-1712

Product Details anti-GP2 Antibody

Binding Specificity: AA 35-179

Specificity: Does not react with Mouse

Purification: Protein G affinity chromatography

Immunogen: A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the GP2 antibody.

Isotype: IgG2b lambda

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/10e6 cells in 0.1ml

Immunofluorescence: 0.5-1 μg/mL

IHC (FFPE): 1-2 μg/mL for 30 min at RT

Optimal dilution of the GP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and Store at -20C. Avoid freez-thaw cycles.

Target Details for GP2

Target: GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))

Alternative Name: Glycoprotein 2

Background: GP2 (Glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

Gene ID: 2813

UniProt: P55259