ITGAL antibody

Catalog No. ABIN6252976

The Mouse Monoclonal anti-ITGAL antibody (Clone TS1-22) (ABIN6252976) specifically detects ITGAL in FACS. The antibody is reactive with Human samples.

Quick Overview for ITGAL antibody (ABIN6252976)

Target: ITGAL (Integrin alpha-L (ITGAL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITGAL antibody is un-conjugated

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: TS1-22

Product Details anti-ITGAL Antibody

Purpose: CD11a Unconjugated Antibody

Characteristics: The clone recognizes a 170-180 kD alpha chain of a type I transmembrane glycoprotein also known as CD11a or LFA-1a. It is also known as LFA-1α. CD11a non-covalently associates with integrin β2 (CD18) to form LFA-1. CD11a is abundantly expressed on all leukocytes, including B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils but does not express by the non-hematopoietic tissues and platelets. Up-regulation of CD11a on activated lymphocytes is required to induce their immune response. Absence or reduced CD11a expression on tumor cells helps to escape from regular immune surveillance and it may be one of reason of in vivo tumor generation.

Purification: Purified

Purity: >95 %

Immunogen: Human HLA-DRCTL line cytolytic Tlymphocytes

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for ITGAL

Target: ITGAL (Integrin alpha-L (ITGAL))

Alternative Name: CD11a

UniProt: P20701

Pathways: Activated T Cell Proliferation, Integrin Complex