CD22 antibody

Catalog No. ABIN6253873

Product Details anti-CD22 Antibody

Target: CD22 (CD22 Molecule (CD22))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD22 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Specificity: B-ly8, produces mouse IgG1 immunoglobulins directed against human CD22, molecular weight 130-140 kD

Purity: PURE

Clone: B-ly8

Isotype: IgG1

Application Details

Application Notes: immunohistochemistry on cytospots, immunohistochemistry on frozen tissue sections

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C

Target Details for CD22

Target: CD22 (CD22 Molecule (CD22))

Alternative Name: CD22 (CD22 Products)

Synonyms: A530093D23 antibody, Lyb-8 antibody, Lyb8 antibody, SIGLEC-2 antibody, SIGLEC2 antibody, siglec-2 antibody, CD22 antigen antibody, CD22 molecule antibody, Cd22 antibody, CD22 antibody

Background: Antigen distribution: CD22 is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface simultaneously with surface IgD, and is found on most mature B cells. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via surface Ig increases CD22 expression [1]. CD22 reacts with most B cell leukemias including Hairy Cell Leukemia (HCL) and B cell lymphomas. Cellular Expression: Pan B cells, (surface and cytoplasmatic staining).