CaMK2 alpha/beta/delta antibody (pThr305)

Catalog No. ABIN6255659

Product Details anti-CaMK2 alpha/beta/delta Antibody

Target: CaMK2 alpha/beta/delta

Binding Specificity: pThr305

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CaMK2 alpha/beta/delta antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: Phospho-CaMK2 alpha/ beta/ delta (Thr305) Antibody detects endogenous levels of CaMK2 alpha/ beta/ delta only when phosphorylated at Threonine 305

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human CaMK2 alpha/ beta/ delta around the phosphorylation site of Threonine 305

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for CaMK2 alpha/beta/delta

Target: CaMK2 alpha/beta/delta

Alternative Name: CaMK2 alpha/ beta/ delta (CaMK2 alpha/beta/delta Products)

Background:

Description: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).

Gene: CAMK2A

Molecular Weight: 54kDa

Gene ID: 815

UniProt: Q9UQM7, Q13554, Q13557