CDK5RAP3 antibody

Catalog No. ABIN6257054

Product Details anti-CDK5RAP3 Antibody

Target: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK5RAP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: CDK5RAP3 Antibody detects endogenous levels of total CDK5RAP3

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide

Isotype: IgG

Application Details

Application Notes: WB 1:500~1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for CDK5RAP3

Target: CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))

Alternative Name: CDK5RAP3 (CDK5RAP3 Products)

Synonyms: cdkrap3 antibody, fb33h04 antibody, fc09c05 antibody, id:ibd2920 antibody, wu:fb33h04 antibody, wu:fc09c05 antibody, zgc:86863 antibody, CDK5RAP3 antibody, cdk5rap3 antibody, MGC82350 antibody, C53 antibody, HSF-27 antibody, IC53 antibody, LZAP antibody, MST016 antibody, OK/SW-cl.114 antibody, PP1553 antibody, 1810007E24Rik antibody, BC002318 antibody, C81486 antibody, CDK5 regulatory subunit associated protein 3 antibody, CDK5 regulatory subunit associated protein 3 L homeolog antibody, cdk5rap3 antibody, CDK5RAP3 antibody, cdk5rap3.L antibody, Cdk5rap3 antibody

Background:

Description: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).

Gene: CDK5RAP3

Molecular Weight: 60 kDa

Gene ID: 80279

UniProt: Q96JB5