RIOK2 antibody (Internal Region)

Catalog No. ABIN6257460

Product Details anti-RIOK2 Antibody

Target: RIOK2 (RIO Kinase 2 (RIOK2))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIOK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Specificity: RIOK2 Antibody detects endogenous levels of total RIOK2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RIOK2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for RIOK2

Target: RIOK2 (RIO Kinase 2 (RIOK2))

Alternative Name: RIOK2 (RIOK2 Products)

Synonyms: wu:fe48f07 antibody, zgc:55376 antibody, zgc:77493 antibody, rio2 antibody, riok2b antibody, RIO2 antibody, 2010110K24Rik antibody, 2410085M17Rik antibody, RIO kinase 2 antibody, RIO kinase 2 (yeast) antibody, RIO kinase 2 S homeolog antibody, Riok2 antibody, riok2 antibody, RIOK2 antibody, riok2.S antibody

Background:

Description: Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).

Gene: RIOK2

Molecular Weight: 63 kDa

Gene ID: 55781

UniProt: Q9BVS4