TEAD3 antibody (Internal Region)

Catalog No. ABIN6257529

The Rabbit Polyclonal anti-TEAD3 antibody is suitable to detect TEAD3 in samples from Human, Mouse and Rat. It has been validated for WB, IF and ICC.

Quick Overview for TEAD3 antibody (Internal Region) (ABIN6257529)

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-TEAD3 Antibody

Binding Specificity: Internal Region

Purpose: TEAD3 Antibody

Specificity: TEAD3 Antibody detects endogenous levels of total TEAD3.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TEAD3, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TEAD3

Target: TEAD3 (TEA Domain Family Member 3 (TEAD3))

Alternative Name: TEAD3

Background:

Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Gene: TEAD3

Molecular Weight: 49 kDa

Gene ID: 7005

UniProt: Q99594

Pathways: Regulation of Lipid Metabolism by PPARalpha