CCNB1IP1 antibody (Internal Region)

Catalog No. ABIN6258548

Product Details anti-CCNB1IP1 Antibody

Target: CCNB1IP1 (Cyclin B1 Interacting Protein 1 (CCNB1IP1))

Binding Specificity: Internal Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCNB1IP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: CCNB1IP1 Antibody detects endogenous levels of total CCNB1IP1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CCNB1IP1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CCNB1IP1

Target: CCNB1IP1 (Cyclin B1 Interacting Protein 1 (CCNB1IP1))

Alternative Name: CCNB1IP1 (CCNB1IP1 Products)

Synonyms: Gm288 antibody, Hei10 antibody, mei4 antibody, C14orf18 antibody, HEI10 antibody, cyclin B1 interacting protein 1 antibody, CCNB1IP1 antibody, BDBG_07921 antibody, Ccnb1ip1 antibody

Background:

Description: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

Gene: CCNB1IP1

Molecular Weight: 32 kDa

Gene ID: 57820

UniProt: Q9NPC3