IL12RB1 antibody (Internal Region)

Catalog No. ABIN6259088

This Rabbit Polyclonal antibody specifically detects IL12RB1 in WB, IHC and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for IL12RB1 antibody (Internal Region) (ABIN6259088)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-IL12RB1 Antibody

Binding Specificity: Internal Region

Specificity: IL12RB1 Antibody detects endogenous levels of total IL12RB1.

Predicted Reactivity: Bovine

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human IL12RB1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Expiry Date: 12 months

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Alternative Name: IL12RB1

Background:

Description: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Gene: IL12RB1

Molecular Weight: 73 kDa

Gene ID: 3594

UniProt: P42701

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation