RFTN1 antibody (Internal Region)

Catalog No. ABIN6259466

Product Details anti-RFTN1 Antibody

Target: RFTN1 (Raftlin, Lipid Raft Linker 1 (RFTN1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFTN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: RFTN1 Antibody detects endogenous levels of total RFTN1.

Predicted Reactivity: Horse,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RFTN1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RFTN1

Target: RFTN1 (Raftlin, Lipid Raft Linker 1 (RFTN1))

Alternative Name: RFTN1 (RFTN1 Products)

Synonyms: RAFTLIN antibody, RGD1310777 antibody, RGD1563347 antibody, 2310015n21rik antibody, mig2 antibody, pig9 antibody, pib10 antibody, raftlin antibody, DKFZp459B0154 antibody, 2310015N21Rik antibody, AI853526 antibody, PIB10 antibody, PIG9 antibody, raftlin, lipid raft linker 1 antibody, raftlin lipid raft linker 1 antibody, RFTN1 antibody, Rftn1 antibody, rftn1 antibody

Background:

Description: Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:27022195, PubMed:21266579). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195, PubMed:21266579). Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling (PubMed:12805216). May play a pivotal role in the formation and/or maintenance of lipid rafts (PubMed:12805216).

Gene: RFTN1

Molecular Weight: 63 kDa

Gene ID: 23180

UniProt: Q14699