Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) antibody Primary Antibody
ADRBK1
Reactivity: Human, Mouse, Rat
ELISA, ICC, IF, IHC, WB
Host: Rabbit
Polyclonal
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Catalog No. ABIN6259807
$390.77
Plus shipping costs $45.00
100 μL ABIN6259807
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- Target
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Conjugate
- Un-conjugated
- Application
- ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- ADRBK1 Antibody detects endogenous levels of total ADRBK1
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ADRBK1
- Isotype
- IgG
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
-
- Target
- Alternative Name
- GRK2 (ADRBK1 Antibody Abstract)
- Synonyms
- Adrbk-1, Bark-1, GRK2, betaARK1, BARK1, BETA-ARK1, GRK-2, Grk2, beta-adrenergic receptor kinase 1, G protein-coupled receptor kinase 2, Tsp_00497, grk2, Grk2, GRK2
- Background
Description: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
Gene: GRK2
- Molecular Weight
- 80kDa
- Gene ID
- 156
- UniProt
- P25098
- Pathways
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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