ARPP19 antibody (N-Term)

Catalog No. ABIN6260049

The Rabbit Polyclonal anti-ARPP19 antibody is suitable to detect ARPP19 in samples from Human, Mouse and Rat. It has been validated for ELISA, IHC and WB.

Quick Overview for ARPP19 antibody (N-Term) (ABIN6260049)

Target: ARPP19 (cAMP-Regulated Phosphoprotein, 19kDa (ARPP19))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARPP19 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-ARPP19 Antibody

Binding Specificity: N-Term

Specificity: ARPP19 Antibody detects endogenous levels of total ARPP19.

Predicted Reactivity: Pig,Bovine,Horse,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ARPP19, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ARPP19

Target: ARPP19 (cAMP-Regulated Phosphoprotein, 19kDa (ARPP19))

Alternative Name: ARPP19

Background:

Description: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

Gene: ARPP19

Molecular Weight: 12 kDa

Gene ID: 10776

UniProt: P56211

Pathways: Regulation of Carbohydrate Metabolic Process