CABP1 antibody (Internal Region)

Catalog No. ABIN6260388

The Rabbit Polyclonal anti-CABP1 antibody is suitable to detect CABP1 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for CABP1 antibody (Internal Region) (ABIN6260388)

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CABP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CABP1 Antibody

Binding Specificity: Internal Region

Purpose: CABP1 Antibody

Specificity: CABP1 Antibody detects endogenous levels of total CABP1.

Predicted Reactivity: Pig,Bovine,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CABP1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CABP1

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Alternative Name: CABP1

Background:

Description: Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs)(PubMed:14570872). Inhibits agonist-induced intracellular calcium signaling (PubMed:15980432). Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels (PubMed:11865310). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function (PubMed:15140941). Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels (PubMed:15895247). Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).

Gene: CABP1

Molecular Weight: 40 kDa

Gene ID: 9478

UniProt: Q9NZU7

Pathways: Synaptic Membrane, Negative Regulation of Transporter Activity