CNGB3 antibody (N-Term)

Catalog No. ABIN6260909

This Rabbit Polyclonal antibody specifically detects CNGB3 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for CNGB3 antibody (N-Term) (ABIN6260909)

Target: CNGB3 (Cyclic Nucleotide Gated Channel beta 3 (CNGB3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNGB3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CNGB3 Antibody

Binding Specificity: N-Term

Specificity: CNGB3 Antibody detects endogenous levels of total CNGB3.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CNGB3, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CNGB3

Target: CNGB3 (Cyclic Nucleotide Gated Channel beta 3 (CNGB3))

Alternative Name: CNGB3

Background:

Description: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.

Gene: CNGB3

Molecular Weight: 92 kDa

Gene ID: 54714

UniProt: Q9NQW8