CTH antibody (N-Term)

Catalog No. ABIN6261082

Product Details anti-CTH Antibody

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTH antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificity: CTH Antibody detects endogenous levels of total CTH.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CTH, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for CTH

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Alternative Name: CTH (CTH Products)

Synonyms: DYT17 antibody, DYT18 antibody, DYT9 antibody, EIG12 antibody, GLUT antibody, GLUT1 antibody, GLUT1DS antibody, HTLVR antibody, PED antibody, wu:fb48e03 antibody, wu:fb58d08 antibody, zgc:66001 antibody, zgc:85785 antibody, CTH antibody, 0610010I13Rik antibody, AI314617 antibody, BC019483 antibody, CSE antibody, Cys3 antibody, cysA antibody, SCQ11.03c antibody, DDBDRAFT_0190313 antibody, DDBDRAFT_0191318 antibody, DDB_0190313 antibody, DDB_0191318 antibody, H antibody, MGC75946 antibody, cystathionine gamma-lyase antibody, solute carrier family 2 member 1 antibody, cystathionase (cystathionine gamma-lyase) antibody, cystathionine gamma-lyase L homeolog antibody, CTH antibody, SLC2A1 antibody, cth antibody, Cth antibody, SCO3920 antibody, mlr1566 antibody, TA_RS00415 antibody, MAP_RS15640 antibody, SPO3344 antibody, CNN01730 antibody, Mmcs_1928 antibody, RHA1_RS31820 antibody, HNE_1212 antibody, MAV_3867 antibody, MSMEG_2394 antibody, Mvan_2142 antibody, SACE_6136 antibody, Mflv_4220 antibody, cysA antibody, cth.L antibody

Background:

Description: Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function.

Gene: CTH

Molecular Weight: 45 kDa

Gene ID: 1491

UniProt: P32929

Pathways: ER-Nucleus Signaling, Warburg Effect