DNAJA1 antibody (C-Term)

Catalog No. ABIN6261327

Product Details anti-DNAJA1 Antibody

Target: DNAJA1 (DnaJ (Hsp40) Homolog, Subfamily A, Member 1 (DNAJA1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNAJA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: DNAJA1 Antibody detects endogenous levels of total DNAJA1.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human DNAJA1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for DNAJA1

Target: DNAJA1 (DnaJ (Hsp40) Homolog, Subfamily A, Member 1 (DNAJA1))

Alternative Name: DNAJA1 (DNAJA1 Products)

Synonyms: DNAJA1 antibody, dj-2 antibody, dja1 antibody, hdj-2 antibody, hdj2 antibody, hsdj antibody, hsj2 antibody, hspf4 antibody, nedd7 antibody, Hsj2 antibody, Nedd7 antibody, DJ-2 antibody, DjA1 antibody, HDJ2 antibody, HSDJ antibody, HSJ2 antibody, HSPF4 antibody, NEDD7 antibody, hDJ-2 antibody, dnaja1l antibody, dnj-12 antibody, wu:fc14c09 antibody, zgc:55650 antibody, dnaJ homolog subfamily A member 1 pseudogene antibody, DnaJ heat shock protein family (Hsp40) member A1 antibody, DnaJ heat shock protein family (Hsp40) member A1 L homeolog antibody, DnaJ (Hsp40) homolog, subfamily A, member 1 antibody, LOC703360 antibody, dnaja1 antibody, DNAJA1 antibody, dnaja1.L antibody, Dnaja1 antibody

Background:

Description: Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).

Gene: DNAJA1

Molecular Weight: 44 kDa

Gene ID: 3301

UniProt: P31689

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway