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FOXN1 antibody (N-Term)

FOXN1 Reactivity: Human, Rat WB, ELISA, ICC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6261798
  • Target See all FOXN1 Antibodies
    FOXN1 (Forkhead Box N1 (FOXN1))
    Binding Specificity
    • 16
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 37
    • 19
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 36
    • 1
    Rabbit
    Clonality
    • 37
    Polyclonal
    Conjugate
    • 13
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FOXN1 antibody is un-conjugated
    Application
    • 32
    • 22
    • 16
    • 13
    • 13
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificity
    FOXN1 Antibody detects endogenous levels of total FOXN1.
    Predicted Reactivity
    Pig,Bovine,Horse,Rabbit
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human FOXN1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product FOXN1 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    FOXN1 (Forkhead Box N1 (FOXN1))
    Alternative Name
    FOXN1 (FOXN1 Products)
    Synonyms
    nude antibody, whnb antibody, FOXN1 antibody, foxN1 antibody, foxN antibody, foxn1 antibody, FKHL20 antibody, RONU antibody, WHN antibody, D11Bhm185e antibody, Fkh19 antibody, HFH-11 antibody, Hfh11 antibody, Whn antibody, nu antibody, Rnu antibody, forkhead box N1 antibody, forkhead box protein N1 antibody, FOXN1 antibody, foxn1 antibody, foxN1 antibody, LOC100125524 antibody, Foxn1 antibody
    Background

    Description: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).

    Gene: FOXN1

    Molecular Weight
    69kDa
    Gene ID
    8456
    UniProt
    O15353
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