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LC3B antibody (N-Term)

MAP1LC3B Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6262925
  • Target See all LC3B (MAP1LC3B) Antibodies
    LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))
    Binding Specificity
    • 23
    • 16
    • 14
    • 12
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 134
    • 50
    • 35
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 123
    • 14
    • 7
    Rabbit
    Clonality
    • 129
    • 16
    Polyclonal
    Conjugate
    • 76
    • 14
    • 13
    • 10
    • 10
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This LC3B antibody is un-conjugated
    Application
    • 88
    • 56
    • 51
    • 27
    • 23
    • 14
    • 13
    • 9
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    LC3A/B Antibody detects endogenous levels of total LC3A/B.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Sheep,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human LC3B, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MAP1LC3B Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Tang, Cui, Luan, Ruan, Wang, Yang, Wang, Liu, Wang: "Human tissue kallikrein 1 ameliorates erectile function via modulation of macroautophagy in aged transgenic rats." in: Andrology, (2018) (PubMed).

    Feng, Lu, He, Wang, Qi, Pi, Zhang: "Mycobacterium smegmatis Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells." in: Frontiers in cellular and infection microbiology, Vol. 8, pp. 201, (2018) (PubMed).

    Shao, Yang, Xu, Zhu, Huang, Li, Wu, Yue, Xiong, Chen, Kuang, Fan, Zhu, Zeng: "Inhibition of mTORC1 signaling protects kidney from irradiation-induced toxicity via accelerating recovery of renal stem-like cells." in: Stem cell research & therapy, Vol. 9, Issue 1, pp. 219, (2018) (PubMed).

    Wu, Zheng, Bai, Xia, Zhang, Guo: "HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma." in: OncoTargets and therapy, Vol. 11, pp. 4501-4510, (2018) (PubMed).

  • Target
    LC3B (MAP1LC3B) (Microtubule-Associated Protein 1 Light Chain 3 beta (MAP1LC3B))
    Alternative Name
    MAP1LC3A,MAP1LC3B (MAP1LC3B Products)
    Synonyms
    ATG8F antibody, LC3B antibody, MAP1A/1BLC3 antibody, MAP1LC3B-a antibody, Map1lc3 antibody, Mpl3 antibody, zbs559 antibody, 1010001C15Rik antibody, Atg8 antibody, LC3b antibody, zgc:56434 antibody, wu:fb60g11 antibody, map1lc3b antibody, MGC76283 antibody, MAP1LC3B antibody, microtubule associated protein 1 light chain 3 beta antibody, microtubule-associated protein 1 light chain 3 beta antibody, microtubule associated protein 1 light chain 3 beta L homeolog antibody, MAP1LC3B antibody, Map1lc3b antibody, map1lc3b antibody, map1lc3b.L antibody
    Background

    Description: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

    Gene: MAP1LC3B

    Molecular Weight
    14.16 kDa
    Gene ID
    84557, 81631
    UniProt
    Q9H492, Q9GZQ8
    Pathways
    Autophagy
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