MCM10 antibody (C-Term)

Catalog No. ABIN6263157

The Rabbit Polyclonal anti-MCM10 antibody is suitable to detect MCM10 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for MCM10 antibody (C-Term) (ABIN6263157)

Target: MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MCM10 Antibody

Binding Specificity: C-Term

Specificity: MCM10 Antibody detects endogenous levels of total MCM10.

Predicted Reactivity: Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human MCM10, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for MCM10

Target: MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))

Alternative Name: MCM10

Background:

Description: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability, acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359).

Gene: MCM10

Molecular Weight: 97-105 kDa

Gene ID: 55388

UniProt: Q7L590

Pathways: Mitotic G1-G1/S Phases, DNA Replication