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MYOC antibody (Internal Region)

MYOC Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6263485
  • Target See all MYOC Antibodies
    MYOC (Myocilin (MYOC))
    Binding Specificity
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 29
    • 14
    • 14
    • 6
    • 2
    Human, Mouse, Rat
    Host
    • 25
    • 4
    Rabbit
    Clonality
    • 26
    • 3
    Polyclonal
    Conjugate
    • 15
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MYOC antibody is un-conjugated
    Application
    • 19
    • 13
    • 9
    • 9
    • 7
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificity
    MYOC Antibody detects endogenous levels of total MYOC.
    Predicted Reactivity
    Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MYOC, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MYOC Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    MYOC (Myocilin (MYOC))
    Alternative Name
    MYOC (MYOC Products)
    Synonyms
    MYOC antibody, MGC136645 antibody, zgc:136645 antibody, AI957332 antibody, GLC1A antibody, TIGR antibody, GPOA antibody, JOAG antibody, JOAG1 antibody, myocilin antibody, Tigr antibody, myocilin antibody, MYOC antibody, myoc antibody, Myoc antibody
    Background

    Description: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.

    Gene: MYOC

    Molecular Weight
    57kDa
    Gene ID
    4653
    UniProt
    Q99972
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