Nkx2-2 antibody (Internal Region)

Catalog No. ABIN6263646

The Rabbit Polyclonal anti-Nkx2-2 antibody is suitable to detect Nkx2-2 in samples from Human, Mouse and Rat. It has been validated for IF, WB and ICC.

Quick Overview for Nkx2-2 antibody (Internal Region) (ABIN6263646)

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nkx2-2 antibody is un-conjugated

Application: Immunofluorescence (IF), Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-Nkx2-2 Antibody

Binding Specificity: Internal Region

Purpose: NKX22 Antibody

Specificity: NKX22 Antibody detects endogenous levels of total NKX22.

Predicted Reactivity: Pig,Bovine,Horse,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NKX22, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for Nkx2-2

Target: Nkx2-2 (NK2 Homeobox 2 (Nkx2-2))

Alternative Name: NKX22

Background:

Description: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).

Gene: NKX2-2

Molecular Weight: 30 kDa

Gene ID: 4821

UniProt: O95096

Pathways: Dopaminergic Neurogenesis