PTPRB antibody (N-Term)

Catalog No. ABIN6264522

The Rabbit Polyclonal anti-PTPRB antibody is suitable to detect PTPRB in samples from Human, Rat and Mouse. It has been validated for WB, IHC and ELISA.

Quick Overview for PTPRB antibody (N-Term) (ABIN6264522)

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPRB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PTPRB Antibody

Binding Specificity: N-Term

Specificity: PTPRB Antibody detects endogenous levels of total PTPRB.

Predicted Reactivity: Pig,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PTPRB, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for PTPRB

Target: PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))

Alternative Name: PTPRB

Background:

Description: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Gene: PTPRB

Molecular Weight: 224kDa

Gene ID: 5787

UniProt: P23467