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TP53BP1 antibody (Tumor Protein P53 Binding Protein 1) Primary Antibody

TP53BP1 Reactivity: Human, Mouse, Rat ELISA, ICC, IF, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6264615
$390.77
Plus shipping costs $45.00
100 μL ABIN6264615
100 μL ABIN6264615
local_shipping Shipping to: United States
Delivery in 8 to 9 Business Days
  • Target
    TP53BP1
    Reactivity
    Human, Mouse, Rat
    • 128
    • 76
    • 52
    • 11
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This TP53BP1 antibody is un-conjugated
    • 67
    • 9
    • 9
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Application
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
    • 67
    • 39
    • 38
    • 27
    • 26
    • 19
    • 16
    • 14
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    Specificity
    TP53BP1 Antibody detects endogenous levels of total TP53BP1
    Cross-Reactivity
    Human, Mouse (Murine), Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human RAD51
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C.Stable for 12 months from date of receipt
    Expiry Date
    12 months
  • Target
    TP53BP1
    Alternative Name
    TP53BP1 (TP53BP1 Antibody Abstract)
    Synonyms
    TP53BP1, MGC160112, 53BP1, Tp53bp1, m53BP1, p202, Trp53bp1, tumor protein p53 binding protein 1, tumor suppressor p53-binding protein 1, tumor protein p53 binding protein 1 (predicted), 5 prime, transformation related protein 53 binding protein 1, TP53BP1, tp53bp1, LOC100550605, Trp53bp1, Tp53bp1
    Background

    Description: Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast, it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).

    Gene: TP53BP1

    Molecular Weight
    213kDa
    Gene ID
    7158
    UniProt
    Q12888
    Pathways
    DNA Damage Repair
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