SIN3B antibody (Internal Region)

Catalog No. ABIN6265088

This Rabbit Polyclonal antibody specifically detects SIN3B in WB, ELISA, IF, IHC and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SIN3B antibody (Internal Region) (ABIN6265088)

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIN3B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Product Details anti-SIN3B Antibody

Binding Specificity: Internal Region

Specificity: Sin3B Antibody detects endogenous levels of total Sin3B.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Sin3B, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SIN3B

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Alternative Name: SIN3B

Background:

Description: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.

Gene: SIN3B

Molecular Weight: 130kDa

Gene ID: 23309

UniProt: O75182