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SKP2 antibody (C-Term)

SKP2 Reactivity: Human, Mouse WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265105
  • Target See all SKP2 Antibodies
    SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
    Binding Specificity
    • 16
    • 8
    • 7
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 70
    • 34
    • 33
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 62
    • 9
    • 1
    Rabbit
    Clonality
    • 61
    • 10
    Polyclonal
    Conjugate
    • 41
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SKP2 antibody is un-conjugated
    Application
    • 50
    • 19
    • 19
    • 16
    • 13
    • 13
    • 13
    • 12
    • 12
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    SKP2/p45 Antibody detects endogenous levels of total SKP2/p45.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SKP2/p45, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SKP2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Zhang, Miao, Li, Cui, Ge, Chen: "S-phase kinase-associated protein 2 impairs the inhibitory effects of miR-1236-3p on bladder tumors." in: American journal of translational research, Vol. 10, Issue 3, pp. 731-743, (2018) (PubMed).

  • Target
    SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
    Alternative Name
    SKP2 (SKP2 Products)
    Synonyms
    FBXL1 antibody, FBL1 antibody, FLB1 antibody, p45 antibody, RGD1562456 antibody, S-phase kinase-associated protein 2 (p45) antibody, S-phase kinase associated protein 2 antibody, Skp2 antibody, SKP2 antibody
    Background

    Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

    Gene: SKP2

    Molecular Weight
    47kDa
    Gene ID
    6502
    UniProt
    Q13309
    Pathways
    Mitotic G1-G1/S Phases
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