SPDYA antibody (Internal Region)

Catalog No. ABIN6265255

Product Details anti-SPDYA Antibody

Target: SPDYA (Speedy Homolog A (SPDYA))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPDYA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Specificity: SPDYA Antibody detects endogenous levels of total SPDYA.

Predicted Reactivity: Pig,Bovine,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SPDYA, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SPDYA

Target: SPDYA (Speedy Homolog A (SPDYA))

Alternative Name: SPDYA (SPDYA Products)

Synonyms: zgc:101624 antibody, 4921517J08Rik antibody, 4930548B21Rik antibody, GS4 antibody, MLZ-465 antibody, Spdy1 antibody, RINGO antibody, SPDY1 antibody, RINGO3 antibody, RINGOA antibody, SPY1 antibody, Gs4 antibody, Lm23 antibody, Spy1 antibody, speedy homolog A (Xenopus laevis) antibody, speedy/RINGO cell cycle regulator family member A antibody, speedy/RINGO cell cycle regulator family, member A antibody, SPDYA antibody, spdya antibody, Spdya antibody

Background:

Description: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962).

Gene: SPDYA

Molecular Weight: 36kDa

Gene ID: 245711

UniProt: Q5MJ70