SYNPO antibody (Internal Region)

Catalog No. ABIN6265395

The Rabbit Polyclonal anti-SYNPO antibody is suitable to detect SYNPO in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for SYNPO antibody (Internal Region) (ABIN6265395)

Target: SYNPO (Synaptopodin (SYNPO))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNPO antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SYNPO Antibody

Binding Specificity: Internal Region

Purpose: Synaptopodin Antibody

Specificity: Synaptopodin Antibody detects endogenous levels of total Synaptopodin.

Predicted Reactivity: Bovine,Horse

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Synaptopodin, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for SYNPO

Target: SYNPO (Synaptopodin (SYNPO))

Alternative Name: Synaptopodin

Background:

Description: Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension, may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes (By similarity). Involved in regulation of cell migration (PubMed:22915763, PubMed:25883213). May be a tumor suppressor (PubMed:16885336).

Gene: SYNPO2

Molecular Weight: 99-115 kDa

Gene ID: 171024

UniProt: Q9UMS6