USP6 antibody (C-Term)

Catalog No. ABIN6265934

This Rabbit Polyclonal antibody specifically detects USP6 in WB and IHC. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for USP6 antibody (C-Term) (ABIN6265934)

Target: USP6 (Ubiquitin Specific Peptidase 6 (USP6))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-USP6 Antibody

Binding Specificity: C-Term

Purpose: USP6 Antibody

Specificity: USP6 Antibody detects endogenous levels of total USP6

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human USP6, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200,WB 1:1000-3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for USP6

Target: USP6 (Ubiquitin Specific Peptidase 6 (USP6))

Alternative Name: USP6

Background:

Description: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Gene: USP6

Molecular Weight: 159 kDa

Gene ID: 9098

UniProt: P35125