ZNRF1 antibody (Internal Region)

Catalog No. ABIN6266142

Product Details anti-ZNRF1 Antibody

Target: ZNRF1 (Zinc and Ring Finger Protein 1 (ZNRF1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNRF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificity: ZNRF1 Antibody detects endogenous levels of total ZNRF1.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZNRF1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ZNRF1

Target: ZNRF1 (Zinc and Ring Finger Protein 1 (ZNRF1))

Alternative Name: ZNRF1 (ZNRF1 Products)

Synonyms: NIN283 antibody, B830022L21Rik antibody, Rnf42 antibody, Zrfp1 antibody, nin283 antibody, zgc:77896 antibody, zrfp1 antibody, zinc and ring finger 1 antibody, zinc and ring finger 1, E3 ubiquitin protein ligase S homeolog antibody, ZNRF1 antibody, Znrf1 antibody, znrf1 antibody, znrf1.S antibody

Background:

Description: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Gene: ZNRF1

Molecular Weight: 24 kDa

Gene ID: 84937

UniProt: Q8ND25