Aurora Kinase B antibody (AA 89-251)

Catalog No. ABIN6294603

This anti-Aurora Kinase B antibody is a Mouse Monoclonal antibody detecting Aurora Kinase B in WB, IF and FACS. Suitable for Human.

Quick Overview for Aurora Kinase B antibody (AA 89-251) (ABIN6294603)

Target: Aurora Kinase B (AURKB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Aurora Kinase B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Aurora Kinase B Antibody

Binding Specificity: AA 89-251

Purpose: Mouse anti-Human Aurora B Antibody / AURKB [Sodium Azide Free]

Specificity: Nuclear, cytoplasmic

Purification: Amino acids 89-251 were used as the immunogen for this Aurora B antibody.

Immunogen: Amino acids 89-251 were used as the immunogen for this Aurora B antibody.

Application Details

Application Notes: Western blot: 0.5-1 μg/mL
FACS: 0.5-1 μg/10e6 cells in 0.1ml
IF: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Alternative Name: Aurora kinase B

Background:

Target Description: Recognizes a protein of 39-45 kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.

Gene Symbol: AURKB///AIK2///AIM1///AIRK2///ARK2///STK1///STK12///STK5

Gene ID: 9212

UniProt: Q96GD4

Pathways: TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades