Filaggrin antibody (AA 998-1104)

Catalog No. ABIN6294618

This anti-Filaggrin antibody is a Mouse Monoclonal antibody detecting Filaggrin in IHC, IF and FACS. Suitable for Human.

Quick Overview for Filaggrin antibody (AA 998-1104) (ABIN6294618)

Target: Filaggrin (FLG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Filaggrin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Filaggrin Antibody

Binding Specificity: AA 998-1104

Purpose: Mouse anti-Human Filaggrin Antibody [Sodium Azide Free]

Specificity: Cytoplasmic

Purification: Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody.

Immunogen: Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody.

Application Details

Application Notes: FACS: 0.5-1 μg/10^6 cells in 0.1ml
IF: 1-2 μg/mL
IHC (FFPE): 0.5-1 μg/mL for 30 min at RT

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Filaggrin

Target: Filaggrin (FLG)

Alternative Name: Filaggrin

Background:

Target Description: Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

Gene Symbol: FLG

Gene ID: 2312

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance