JUP antibody (N-Term)

Catalog No. ABIN6295501

This Mouse Monoclonal antibody specifically detects JUP in WB, IF and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for JUP antibody (N-Term) (ABIN6295501)

Target: JUP (Junction Plakoglobin (JUP))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This JUP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-JUP Antibody

Binding Specificity: N-Term

Purpose: Mouse anti-Human/Mouse Gamma Catenin Antibody / Plakoglobin [Sodium Azide Free]

Specificity: Cell surface, cytoplasmic, cell junctions

Purification: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Immunogen: Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.

Application Details

Application Notes: Immunofluorescence: 1-2 μg/mL
WB: 0.5-1 μg/mL
Immunoprecipitation: suitable

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for JUP

Target: JUP (Junction Plakoglobin (JUP))

Alternative Name: Junction plakoglobin

Background:

Target Description: It recognizes a protein of 80-87 kDa, identified as gamma-Catenin or Plakoglobin. The catenins (alpha, beta, gamma and δ,) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.

Gene Symbol: JUP///CTNNG///DP3

Gene ID: 3728

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location