Tyrosinase-Related Protein 1 antibody

Catalog No. ABIN6295921

This Mouse Monoclonal antibody specifically detects Tyrosinase-Related Protein 1 in IHC, IF and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for Tyrosinase-Related Protein 1 antibody (ABIN6295921)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Purpose: Mouse anti-Human/Mouse TRP1 Antibody [Sodium Azide Free]

Specificity: Cytoplasmic

Purification: Recombinant full-length human protein was used as the immunogen for the TRP1 antibody.

Immunogen: Recombinant full-length human protein was used as the immunogen for the TRP1 antibody.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Immunohistochemistry (FFPE): 2-4 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: 5,6-dihydroxyindole-2-carboxylic acid oxidase

Background:

Target Description: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Gene Symbol: TYRP1///CAS2///TYRP///TYRRP

Gene ID: 7306

UniProt: P17643