UACA antibody

Catalog No. ABIN6296769

This anti-UACA antibody is a Mouse Monoclonal antibody detecting UACA in WB, IF and FACS. Suitable for Human and Mouse.

Quick Overview for UACA antibody (ABIN6296769)

Target: UACA (Uveal Autoantigen With Coiled Coil Domains And Ankyrin Repeats (UACA))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This UACA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-UACA Antibody

Purpose: Mouse anti-Human/Mouse UACA Antibody [Sodium Azide Free]

Specificity: Nuclear membrane

Purification: Nuclei of myeloid leukemia biopsy cells were used as the immunogen for the UACA antibody.

Immunogen: Nuclei of myeloid leukemia biopsy cells were used as the immunogen for the UACA antibody.

Application Details

Application Notes: Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for UACA

Target: UACA (Uveal Autoantigen With Coiled Coil Domains And Ankyrin Repeats (UACA))

Alternative Name: Uveal autoantigen with coiled-coil domains and ankyrin repeats

Background:

Target Description: UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

Gene Symbol: UACA///KIAA1561

Gene ID: 55075

UniProt: Q9BZF9

Pathways: Positive Regulation of Endopeptidase Activity