ErbB2/Her2 antibody

Catalog No. ABIN6297525

The Mouse Monoclonal anti-ErbB2/Her2 antibody (ABIN6297525) specifically detects ErbB2/Her2 in IF and FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for ErbB2/Her2 antibody (ABIN6297525)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-ErbB2/Her2 Antibody

Purpose: Mouse anti-Human/Rat ErbB2 Antibody HER2 [Sodium Azide Free]

Specificity: Extracellular/Intracellular cell membrane

Purification: Recombinant human protein was used as the immunogen for this ErbB2 antibody.(1)

Immunogen: Recombinant human protein was used as the immunogen for this ErbB2 antibody.(1)

Application Details

Application Notes: FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: Receptor tyrosine-protein kinase erbB-2

Background:

Target Description: This antibody recognizes a protein of 185 kDa, which is identified as HER2 / ErbB2. Its epitope is localized in the extracellular domain. ErbB2 is a member of the EGFR family. This antibody is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. ErbB2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.

Gene Symbol: ERBB2///HER2///MLN19///NEU///NGL

Gene ID: 2064

UniProt: P04626

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development