SUMO3 antibody

Catalog No. ABIN6297569

The Mouse Monoclonal anti-SUMO3 antibody has been validated for IHC. It is suitable to detect SUMO3 in samples from Human.

Quick Overview for SUMO3 antibody (ABIN6297569)

Target: SUMO3 (Small Ubiquitin Related Modifier 3 (SUMO3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SUMO3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-SUMO3 Antibody

Purpose: Mouse anti-Human SUMO2/3 Antibody [IHC only]

Specificity: Predominantly nuclear with some cytoplasmic

Purification: Recombinant human SUMO2 protein was used as the immunogen for this SUMO2/3 antibody.

Immunogen: Recombinant human SUMO2 protein was used as the immunogen for this SUMO2/3 antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for SUMO3

Target: SUMO3 (Small Ubiquitin Related Modifier 3 (SUMO3))

Alternative Name: Small ubiquitin-related modifier 3

Background:

Target Description: This antibody reacts with both SUMO2 and SUMO3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO1, 2 and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursors that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets for a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO1/2/3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO1 utilizes Ubc9 for conjugation to several targets, which include MDM2, p53, PML and RanGap1. SUMO2/3 contribute to a greater percentage of protein modification than does SUMO1 and they can form polymeric chains. In addition, SUMO3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer 's disease.

Gene Symbol: SUMO3///SMT3A///SMT3H1

Gene ID: 6613

UniProt: P55854