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Integrin beta 4 antibody

The Mouse Monoclonal anti-Integrin beta 4 antibody has been validated for FACS, IF, Func and BP. It is suitable to detect Integrin beta 4 in samples from Human.
Catalog No. ABIN6297743

Quick Overview for Integrin beta 4 antibody (ABIN6297743)

Target

See all Integrin beta 4 (ITGB4) Antibodies
Integrin beta 4 (ITGB4)

Reactivity

  • 91
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  • 4
  • 4
Human

Host

  • 65
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  • 2
Mouse

Clonality

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Monoclonal

Conjugate

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  • 2
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  • 1
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  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
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  • 1
This Integrin beta 4 antibody is un-conjugated

Application

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Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func), Blocking Peptide (BP)
  • Purpose

    Mouse anti-Human Integrin Beta-4 Antibody [Sodium Azide Free]

    Specificity

    Cell surface

    Purification

    The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.

    Immunogen

    The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.
  • Application Notes

    Functional Blocking: partially blocks laminin binding, order the BSA/azide free format
    FACS: 0.5-1 μg/million cells
    IF: 0.5-1 μg/mL

    Restrictions

    For Research Use only
  • Buffer

    In 1X PBS ( pH 7.4), BSA free, sodium azide free

    Preservative

    Azide free

    Storage

    4 °C,-20 °C

    Storage Comment

    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • Target

    Integrin beta 4 (ITGB4)

    Alternative Name

    Integrin beta-4

    Background

    Target Description: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of < font face=symbol>a and < font face=symbol>b subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of < font face=symbol>a and < font face=symbol>b polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

    Gene Symbol: ITGB4

    Gene ID

    3691

    UniProt

    P16144

    Pathways

    Integrin Complex
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