Integrin beta 4 antibody (ITGB4)

Details for Product anti-ITGB4 Antibody No. ABIN6297743
Antigen
  • AA407042
  • C230078O20
  • CD104
  • integrin subunit beta 4
  • integrin beta 4
  • ITGB4
  • Itgb4
Reactivity
Human
217
86
56
5
5
1
1
Host
Mouse
125
96
26
2
2
Clonality
Monoclonal
Conjugate
This Integrin beta 4 antibody is un-conjugated
13
12
5
5
5
5
5
5
3
3
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Blocking Peptide (BP), Flow Cytometry (FACS), Functional Studies (Func), Immunofluorescence (IF)
162
113
94
65
56
42
33
30
26
13
9
9
4
2
2
2
1
Options
Purpose Mouse anti-Human Integrin Beta-4 Antibody [Sodium Azide Free]
Immunogen The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.
Specificity Cell surface
Purification The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.
Plasmids, Primers & others Plasmids, Primers & others Integrin beta 4 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Integrin beta-4 (ITGB4 Antibody Abstract)
Background

Target Description: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of < font face=symbol>a and < font face=symbol>b subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of < font face=symbol>a and < font face=symbol>b polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene Symbol: ITGB4

Gene ID 3691
UniProt P16144
Pathways Integrin Complex
Application Notes Functional Blocking: partially blocks laminin binding, order the BSA/azide free format
FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer In 1X PBS ( pH 7.4), BSA free, sodium azide free
Preservative Azide free
Storage 4 °C,-20 °C
Storage Comment 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
Did you look for something else?