Integrin beta 4 antibody

Catalog No. ABIN6297743

Product Details anti-Integrin beta 4 Antibody

Target: Integrin beta 4 (ITGB4)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func), Blocking Peptide (BP)

Purpose: Mouse anti-Human Integrin Beta-4 Antibody [Sodium Azide Free]

Specificity: Cell surface

Purification: The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.

Immunogen: The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.

Application Details

Application Notes: Functional Blocking: partially blocks laminin binding, order the BSA/azide free format
FACS: 0.5-1 μg/million cells
IF: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: In 1X PBS ( pH 7.4), BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for Integrin beta 4

Target: Integrin beta 4 (ITGB4)

Alternative Name: Integrin beta-4 (ITGB4 Products)

Synonyms: AA407042 antibody, C230078O20 antibody, CD104 antibody, integrin subunit beta 4 antibody, integrin beta 4 antibody, ITGB4 antibody, Itgb4 antibody

Background:

Target Description: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of < font face=symbol>a and < font face=symbol>b subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of < font face=symbol>a and < font face=symbol>b polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene Symbol: ITGB4

Gene ID: 3691

UniProt: P16144

Pathways: Integrin Complex