KNG1 antibody (Biotin)

Catalog No. ABIN6297826

This Rabbit Polyclonal antibody specifically detects KNG1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for KNG1 antibody (Biotin) (ABIN6297826)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Product Details anti-KNG1 Antibody (Biotin)

Purpose: Rabbit anti-Human Bradykinin [+Biotin] Antibody,

Immunogen: This antibody was produced from antiserum of rabbits immunized with a polypeptide immunogen. The IgG fraction was purified by Protein G/A affinity chromatography.

Isotype: IgG

Application Details

Application Notes: ELISA (recommended work dilution= 1:16,000), Western Blotting (recommended work dilution= 1:1,000-5,002),

Restrictions: For Research Use only

Handling

Reconstitution: Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/mL.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: -20°C

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: Kininogen-1 , Kininogen-1 light chain, Low molecular weight growth-promoting factor]

Background:

Target Description: Bradykinin is a potent endothelium-dependent vasodilator, leading to a drop in blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.Bradykinin also causes natriuresis, contributing to the drop in blood pressure.Bradykinin raises internal calcium levels in neocortical astrocytes causing them to release glutamate.Bradykinin is also thought to be the cause of the dry cough in some patients on angiotensin-converting enzyme (ACE) inhibitor drugs. It is thought that bradykinin is converted to inactive metabolites by ACE, therefore inhibition of this enzyme leads to increased levels of bradykinin, which causes a dry cough via bronchoconstriction. This refractory cough is a common cause for stopping ACE inhibitor therapy, in which case angiotensin II receptor antagonists (ARBs) are the next line of treatment.Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema, formerly known as hereditary angio-neurotic edema.

Gene Symbol: KNG1///BDK///KNG

Gene ID: 3827

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process