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MAVS antibody (N-Term)

MAVS Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN635035
  • Target See all MAVS Antibodies
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Binding Specificity
    • 15
    • 13
    • 9
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 49
    • 38
    • 4
    • 2
    • 1
    Human
    Host
    • 70
    • 7
    Rabbit
    Clonality
    • 72
    • 5
    Polyclonal
    Conjugate
    • 35
    • 6
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MAVS antibody is un-conjugated
    Application
    • 69
    • 37
    • 13
    • 13
    • 11
    • 9
    • 9
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    VISA antibody was raised against the N terminal of VISA
    Purification
    Affinity purified
    Immunogen
    VISA antibody was raised using the N terminal of VISA corresponding to a region with amino acids ETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGH
    Top Product
    Discover our top product MAVS Primary Antibody
  • Application Notes
    WB: 1 µg/mL
    Optimal conditions should be determined by the investigator.
    Comment

    VISA Blocking Peptide, catalog no. 33R-2767, is also available for use as a blocking control in assays to test for specificity of this VISA antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of VISA antibody in PBS
    Concentration
    Lot specific
    Buffer
    PBS
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Target
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Alternative Name
    VISA (MAVS Products)
    Synonyms
    CARDIF antibody, IPS-1 antibody, IPS1 antibody, VISA antibody, D430028G21Rik antibody, Visa antibody, cardif antibody, wu:fj20d04 antibody, zgc:158392 antibody, mitochondrial antiviral signaling protein antibody, MAVS antibody, Mavs antibody, mavs antibody
    Background
    Double-stranded RNA viruses are recognised in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI (ROBO3). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA.
    Molecular Weight
    56 kDa (MW of target protein)
    Pathways
    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
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